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Men's Health · 3 min read

What Is Enclomiphene?

The oral path to higher testosterone — without shutting down fertility.

The mechanism

Enclomiphene is a SERM (selective estrogen receptor modulator) that blocks estrogen feedback at the pituitary, causing increased LH/FSH and ultimately higher endogenous T.

vs. Clomid

Enclomiphene is the active isomer of clomiphene (Clomid). The other isomer (zuclomiphene) has a longer half-life and worse side-effect profile.

Typical results

Most patients see a 100–150% increase in total testosterone within 12 weeks.

Fertility preserved

Unlike TRT, enclomiphene preserves spermatogenesis — making it the choice for men still planning to have children.

Side effects

Mild and uncommon: mood changes, headache, rare visual disturbances. Reversible with discontinuation.

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